反应详情

[3-Fluoro-4-(4-methyl-[1,2,3]-triazol-1-yl)-phenyl]-carbamic acid benzyl ester (Intermediate 20) (56 g, 0.17 mol), lithium hexamethyldisilazide (LiHMDS) (1M/THF, 200 ml, 0.20 mol) and R-(−)-glycidyl butyrate (25 ml, 0.18 mol) were reacted following the procedure described for Intermediate 25. Chromatography on silica gel with 0-40% acetone in ethyl acetate, followed by trituration with acetone/ethyl acetate/chloroform/hexanes (300 ml/100 ml/100 ml/500 ml) overnight gave the title compound as an off-white solid (33.9 g), m.p. 190.2-192.0° C.