HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-[3-Fluoro-4-(4-methyl-1,2,4-triazol-1-yl)phenyl]-5-(aminomethyl)-oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (5S)-5-(Aminomethyl)-3-[3-Fluoro-4-(4-methyl-1,2,3-triazol-1-yl)phenyl]-1,3-oxazolidin-2-one | HCID 57526957 | — |
| Reactant | 3-[3-Fluoro-4-(3-methyl-1,2,4-triazol-1-yl)phenyl]-5-(azidomethyl)oxazolidin-2-one | HCID 76556215 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[3-Fluoro-4-(4-methyl-1,2,4-triazol-1-yl)phenyl]-5-(aminomethyl)-oxazolidin-2-one | HCID 77563819 | — |
Reaction Steps
3-[3-Fluoro-4-(3-methyl-1,2,4-triazol-1-yl)phenyl]-5-(azidomethyl)oxazolidin-2-one (Intermediate 24) (1.8 g, 5.67 mmol) was hydrogenated as described for Intermediate 16. Chromatography on silica gel with 3-7% methanol in dichloromethane gave the title compound (1.28 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07473699B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-088d650f84784044a5be4a5d8c7dca16 |
| Source note | uspto-grants-2009_01 |