HCID 86598351, compound → (5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3,5-difluorophenyl]-5-[(5-propyl-2H-tetrazol-2-yl)methyl]oxazolidin-2-one

HRID 1452595Notes

Reaction equation

HRID 1452595 reaction equation
[CH2:1]([C:4]1[NH:8][N:7]=[N:6][N:5]=1)[CH2:2][CH3:3].N([CH2:12][C@H:13]1[O:17][C:16](=[O:18])[N:15]([C:19]2[CH:24]=[C:23]([F:25])[C:22]([C:26]3[CH2:27][CH2:28][S:29](=[O:33])(=[O:32])[CH2:30][CH:31]=3)=[C:21]([F:34])[CH:20]=2)[CH2:14]1)=[N+]=[N-]>>[O:33]=[S:29]1(=[O:32])[CH2:28][CH:27]=[C:26]([C:22]2[C:23]([F:25])=[CH:24][C:19]([N:15]3[CH2:14][C@H:13]([CH2:12][N:6]4[N:7]=[N:8][C:4]([CH2:1][CH2:2][CH3:3])=[N:5]4)[O:17][C:16]3=[O:18])=[CH:20][C:21]=2[F:34])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 86598351HCID 86598351, compoundHCID 178440452HCID 178440452, compound

Product 1

HCID 10026918(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3,5-difluorophenyl]-5-[(5-propyl-2H-tetrazol-2-yl)methyl]oxazolidin-2-one

Procedure

This compound was prepared from 5-propyl-1H-tetrazole (0.187 g, 1.67 mmol) and (5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3,5-difluorophenyl]-5-(hydroxymethyl)oxazolidin-2-one (WO 01/81350 A1) (0.30 g, 0.84 mmol) as described for Example 29. The title compound was obtained as a colourless solid (0.25 g).

Sources & evidence

ORD record
ord-62bccf8440744339a12227773ac1610d
Source dataset
uspto-grants-2009_01
Patent number
US07473699B2

Reaction notes

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