HCID 57526844, compound → HCID 57526804, compound

HRID 1452637Notes

Reaction equation

HRID 1452637 reaction equation
[C:1]([O:5][C:6]([N:8]([C:36]1[CH:41]=[CH:40][C:39]([O:42][CH2:43][CH3:44])=[CH:38][CH:37]=1)[C:9]1[N:10]2[C:14]([N:15]=[C:16]3[N:22]([C@H:23]4[CH2:28][CH2:27][CH2:26][N:25]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:24]4)[CH2:21][CH:20]=[CH:19][CH2:18][C:17]=13)=[CH:13][CH:12]=[N:11]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[C:1]([O:5][C:6]([N:8]([C:36]1[CH:37]=[CH:38][C:39]([O:42][CH2:43][CH3:44])=[CH:40][CH:41]=1)[C:9]1[N:10]2[C:14]([N:15]=[C:16]3[N:22]([C@H:23]4[CH2:28][CH2:27][CH2:26][N:25]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:24]4)[CH2:21][CH2:20][CH2:19][CH2:18][C:17]=13)=[CH:13][CH:12]=[N:11]2)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 57526844HCID 57526844, compound

Product 1

HCID 57526804HCID 57526804, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

tert-Butyl(S)-3-{10-[tert-butoxycarbonyl-(4-ethoxyphenyl)amino]-6,9-dihydro-1,4,5,10a-tetraazacyclohepta[f]inden-5-yl}piperidine-1-carboxylate (12.5 mg) was hydrogenated in the presence of palladium-carbon (15 mg) in ethanol (1.2 mL) under a hydrogen atmosphere. After the reaction, the palladium-carbon was filtered off, and the filtrate was concentrated. The residue was used for the subsequent reaction without purification.

Workup

  1. customAfter the reaction
  2. filtrationthe palladium-carbon was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was used for the subsequent reaction without purification

Sources & evidence

ORD record
ord-79e18c62ba56475fa1119949fcba6812
Source dataset
uspto-grants-2009_01
Patent number
US07473694B2

Reaction notes

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