Dichloromethane → HCID 57526847, compound

HRID 1452641Notes

Reaction equation

HRID 1452641 reaction equation
C(Cl)Cl.[CH2:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]2[N:25]3[C:21](=[CH:22][CH:23]=[N:24]3)[N:20]=[C:19]3[C:15]=2[CH2:16][CH2:17][N:18]3[OH:26])=[CH:9][CH:8]=1)[CH3:5].[C:27](OC(=O)C)(=[O:29])[CH3:28]>C(N(CC)CC)C>[C:27]([O:26][N:18]1[CH2:17][CH2:16][C:15]2[C:19]1=[N:20][C:21]1[N:25]([C:14]=2[NH:13][C:10]2[CH:9]=[CH:8][C:7]([O:6][CH2:4][CH3:5])=[CH:12][CH:11]=2)[N:24]=[CH:23][CH:22]=1)(=[O:29])[CH3:28]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 57526817HCID 57526817, compound

Product 1

HCID 57526847HCID 57526847, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a methylene chloride (0.5 mL) solution containing 8-(4-ethoxyphenylamino)-6,7-dihydro-1,4,5,8a-tetraaza-s-indacen-5-ol (2.8 mg), triethylamine (50 μL) and acetic anhydride (50 μL) were added. After this solution was stirred at room temperature for 30 min, the solvent was concentrated, and the residue was purified with PTLC (70% ethyl acetate-hexane) to obtain the title compound (2.3 mg).

Workup

  1. additionwere added
  2. concentrationthe solvent was concentrated
  3. customthe residue was purified with PTLC (70% ethyl acetate-hexane)

Sources & evidence

ORD record
ord-a78ec0441b574972a822c60224d230b1
Source dataset
uspto-grants-2009_01
Patent number
US07473694B2

Reaction notes

Loading…