Methanesulfonyl chloride → 3-methylsulfonylamino-5-nitro-1H-indazole

HRID 1452860Notes

Reaction equation

HRID 1452860 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=2)[NH:4][N:3]=1.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>N1C=CC=CC=1>[CH3:14][S:15]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=2)[NH:4][N:3]=1)(=[O:17])=[O:16]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 31366553-Amino-5-nitroindazole

Product 1

HCID 225672013-methylsulfonylamino-5-nitro-1H-indazoleYield 84.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Methylsulfonylamino-5-nitro-1H-indazole can be obtained as described in Example 2 from 0.7 g of 3-amino-5-nitro-1H-indazole, 23 ml of pyridine and 0.455 g of methylsulfonyl chloride. 0.85 g of 3-methylsulfonylamino-5-nitro-1H-indazole is thus obtained in the form of an orange powder used as it is in the following step.

Sources & evidence

ORD record
ord-258781a826894dd9831e0358f5a3dd02
Source dataset
uspto-grants-2009_01
Patent number
US07473701B2

Reaction notes

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