Sodium Hydroxide → Sodium 6-methoxynicotinate

HRID 1453483Notes

Reaction equation

HRID 1453483 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[CH:5][N:4]=1.[OH-].[Na+:14]>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O-:9])=[O:8])=[CH:5][N:4]=1.[Na+:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 586039Methyl 6-methoxypyridine-3-carboxylate

Product 1

HCID 23717611Sodium 6-methoxynicotinate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

methyl 6-methoxynicotinate (2.097 g, 12.56 mmol) was dissolved in dioxane (30 mL). An aqueous solution of NaOH (1.0N, 25 mL) was added to the solution and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure to provide 2.2 g of sodium 6-methoxynicotinate.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-e2d8fa50ed5c42fdb9b6db3e1b916b41
Source dataset
uspto-grants-2009_01
Patent number
US07476399B2

Reaction notes

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