Thiophene-3-carboxylic acid → Thiophene-3-carboxylic Acid 4-trifluoromethoxy-benzylamide

HRID 1453490Notes

Reaction equation

HRID 1453490 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.[F:9][C:10]([F:21])([F:20])[O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH2:17])=[CH:14][CH:13]=1>>[F:9][C:10]([F:20])([F:21])[O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:17][C:6]([C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)=[O:8])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 6918Thiophene-3-carboxylic acidHCID 5718464-(Trifluoromethoxy)benzylamine

Product 1

HCID 33312067Thiophene-3-carboxylic Acid 4-trifluoromethoxy-benzylamide

Procedure

Prepared in a similar manner to example 4 using thiophene-3-carboxylic acid and 4-trifluoromethoxy-benzylamine. MS (M+H, 302.0).

Sources & evidence

ORD record
ord-c4138b7b00a04186b159952f01f1eb10
Source dataset
uspto-grants-2009_01
Patent number
US07476399B2

Reaction notes

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