Triethylamine → HCID 68821681, compound

HRID 1453535Notes

Reaction equation

HRID 1453535 reaction equation
[Cl:1][C:2]1[S:10][C:9]2[S:8](=[O:12])(=[O:11])[NH:7][CH2:6][N:5]([CH2:13][CH3:14])[C:4]=2[CH:3]=1.[N-:15]=[C:16]=[O:17].[CH2:18](N(CC)CC)[CH3:19]>CC#N>[Cl:1][C:2]1[S:10][C:9]2[S:8](=[O:12])(=[O:11])[N:7]([C:16]([NH:15][CH2:18][CH3:19])=[O:17])[CH2:6][N:5]([CH2:13][CH3:14])[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 105034IsocyanateHCID 11184334HCID 11184334, compound

Product 1

HCID 68821681HCID 68821681, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

200 mg of the compound of Example 3 are dissolved in 1.5 ml of CH3CN. 1 ml of ethyl to isocyanate and 0.2 ml of triethylamine are then added to the solution. The reaction mixture is stirred at ambient temperature for 2 hours At the end of that period, the solvents are removed in vacuo. The residue is dissolved in a minimum of acetone. The product is then precipitated by gradual addition of water. The product is quickly collected by filtration, washed with water and then dried.

Workup

  1. customthe solvents are removed in vacuo
  2. dissolutionThe residue is dissolved in a minimum of acetone
  3. customThe product is then precipitated by gradual addition of water
  4. filtrationThe product is quickly collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-ed12ed4c40154a05b97d162ac7f25be3
Source dataset
uspto-grants-2009_01
Patent number
US07476668B2

Reaction notes

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