Methyl iodide → HCID 68821354, compound

HRID 1453538Notes

Reaction equation

HRID 1453538 reaction equation
[CH3:1][C:2]1[C:10]2[S:9](=[O:12])(=[O:11])[N:8]=[CH:7][NH:6][C:5]=2[S:4][CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].IC>C(#N)C>[CH3:13][N:6]1[C:5]2[S:4][CH:3]=[C:2]([CH3:1])[C:10]=2[S:9](=[O:12])(=[O:11])[N:8]=[CH:7]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 68822180HCID 68822180, compound

Product 1

HCID 68821354HCID 68821354, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
65 °C

Procedure

150 mg of the compound obtained in Step A above are suspended in 5 ml of acetonitrile. 300 mg of potassium carbonate and 0.15 ml of iodomethane are added thereto. The reaction mixture is heated at 65° C. for 30 minutes, with stirring. After evaporation of the solvents under reduced pressure, the residue is taken up in 5 ml of water and then collected by filtration, washed with water and dried.

Workup

  1. customAfter evaporation of the solvents under reduced pressure
  2. filtrationcollected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-57a84ff683de44b3b0c3dea3656a3a01
Source dataset
uspto-grants-2009_01
Patent number
US07476668B2

Reaction notes

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