反应详情

A mixture of 365 mg 2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 265 mg 2-chloromethyl-4-methyl-quinazoline and 210 mg potassium carbonate in 6 ml acetonitrile is stirred for 17 h at ambient temperature. Then the reaction mixture is filtered through 5 g aluminium oxide with ethyl acetate and the filtrate is evaporated down. The residue is triturated in diisopropylether, separated from the ether and dried.

1. filtrationThen the reaction mixture is filtered through 5 g aluminium oxide with ethyl acetate
2. customthe filtrate is evaporated down
3. customThe residue is triturated in diisopropylether
4. customseparated from the ether
5. customdried