Methylamine → HCID 178482400, compound

HRID 1453566Notes

Reaction equation

HRID 1453566 reaction equation
[N:1]1([C:10]2[N:18]=[C:17](Cl)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:20][NH2:21]>CS(C)=O>[N:1]1([C:10]2[N:18]=[C:17]([NH:21][CH3:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178478376HCID 178478376, compound

Product 1

HCID 178482400HCID 178482400, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

200 mg of product obtained in stage 1 above are mixed with 2 ml of DMSO and 0.115 ml (5 equivalents) of methylamine, and the mixture is then heated at 120° C. for approximately 18 hours. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-1 mixture for eluent. Evaporation is carried out and a paste is formed in methylene chloride. Partial drying and drying under vacuum at 50° C. are carried out. 190 mg of expected product are obtained.

Workup

  1. customto return to ambient temperature
  2. customPurification
  3. customEvaporation
  4. customa paste is formed in methylene chloride
  5. customPartial drying
  6. customdrying under vacuum at 50° C.

Sources & evidence

ORD record
ord-31be6f77aead48008b67fdcdfb320223
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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