反应详情

温度

120 °C

200 mg of product obtained in stage 1 above are mixed with 2 ml of DMSO and 0.115 ml (5 equivalents) of methylamine, and the mixture is then heated at 120° C. for approximately 18 hours. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-1 mixture for eluent. Evaporation is carried out and a paste is formed in methylene chloride. Partial drying and drying under vacuum at 50° C. are carried out. 190 mg of expected product are obtained.

1. customto return to ambient temperature
2. customPurification
3. customEvaporation
4. customa paste is formed in methylene chloride
5. customPartial drying
6. customdrying under vacuum at 50° C.