Cyclohexylamine → HCID 178419902, compound

HRID 1453568Notes

Reaction equation

HRID 1453568 reaction equation
[N:1]1([C:10]2[N:18]=[C:17](Cl)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH:20]1([NH2:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>CS(C)=O>[N:1]1([C:10]2[N:18]=[C:17]([NH:26][CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 178478376HCID 178478376, compound

Product 1

HCID 178419902HCID 178419902, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
110 °C

Procedure

200 mg of product obtained in stage 1 above are mixed with 2 ml of DMSO and 0.42 ml of cyclohexylamine, and the mixture is then heated at 110° C. for approximately 48 hours. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-1 mixture for eluent. 84.7 mg of expected product are obtained.

Workup

  1. customto return to ambient temperature
  2. customPurification

Sources & evidence

ORD record
ord-0c349a75dd754630bd30f2f39de27332
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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