HRID1453579

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5798

Benzimidazole

C7H6N2

HCID7657

Dibenzyl ether

C14H14O

HCID58285232

2,6-Dichloro-9-{[2-(trimethylsilyl)ethoxy]methyl}-9H-purine

C11H16Cl2N4OSi

HCID178420378

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCOCn1cnc2c(-n3cnc4ccc(OCc5ccccc5)cc43)nc(Cl)nc21

HCID86614102

未命名化合物

收率 48.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID263

1-Butanol

C4H10O

CONDITIONS

反应条件

温度: 120 °C

PROCEDURE

实验过程

860 mg of product obtained in stage 1 above are mixed with 605 mg of 5-(phenylmethoxy)-1H-benzimidazole (benzyl ether in the 5-position of benzimidazole) and 15 ml of butanol. The mixture is heated at 120° C. for 24 hours. Partial drying, washing with H2O and then drying under vacuum at 50° C. are carried out. 667 mg of 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl)ethoxy]methyl]-9H-purine are obtained, in the form of beige-colored crystals.

WORKUP

后处理

customPartial drying
washwashing with H2O
customdrying under vacuum at 50° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f128de6f5f6748459fc36bcee54d9c29
来源数据集: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07476670B2
来源说明: uspto-grants-2009_01

反应 SMILES

[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:17])[CH3:16])=[C:4](Cl)[N:3]=1.[C:20]1([CH2:26][O:27][C:28]2[CH:36]=[CH:35][C:31]3[NH:32][CH:33]=[N:34][C:30]=3[CH:29]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(OCC1C=CC=CC=1)C1C=CC=CC=1.N1C2C=CC=CC=2NC=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:17])[CH3:16])=[C:4]([N:34]2[C:30]3[CH:29]=[C:28]([O:27][CH2:26][C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH:36]=[CH:35][C:31]=3[N:32]=[CH:33]2)[N:3]=1