HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1453579Generated: October 25, 2026
Benzimidazole → 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl) ethoxy]methyl]-9H-purine
https://huagongshe.com/reaction/1453579
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | Dibenzyl ether | HCID 7657 | — |
| Reactant | 2,6-Dichloro-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine | HCID 58285232 | — |
| Reactant | HCID 178420378 | HCID 178420378 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl) ethoxy]methyl]-9H-purine | HCID 86614102 | 48.8% |
Reaction Steps
860 mg of product obtained in stage 1 above are mixed with 605 mg of 5-(phenylmethoxy)-1H-benzimidazole (benzyl ether in the 5-position of benzimidazole) and 15 ml of butanol. The mixture is heated at 120° C. for 24 hours. Partial drying, washing with H2O and then drying under vacuum at 50° C. are carried out. 667 mg of 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl)ethoxy]methyl]-9H-purine are obtained, in the form of beige-colored crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07476670B2 |
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| Source dataset | uspto-grants-2009_01 |
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| ORD ID | ord-f128de6f5f6748459fc36bcee54d9c29 |
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| Source note | uspto-grants-2009_01 |
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