2-Methylindoline → HCID 178421929, compound

HRID 1453588Notes

Reaction equation

HRID 1453588 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[CH3:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14]1>C(O)CCC>[CH3:12][C:13]1[N:14]([C:4]2[N:3]=[C:2]([Cl:1])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)[C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][CH:16]=2

Participants

4

Reactant 2

HCID 233052-MethylindolineHCID 53244122,6-Dichloropurine

Product 1

HCID 178421929HCID 178421929, compoundYield 61.3%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
130 °C

Procedure

The same procedure as in stage 1 of Example 1 is carried out, mixing 189 mg of 2,6-dichloropurine, 5 ml of butanol and 0.16 g of 2-methylindoline. The mixture is heated at 130° C. for approximately 1 hour and allowed to return to ambient temperature. Partial drying is carried out, followed by washing with isopropanol. The product is dried and 174 mg of expected product are thus obtained.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washby washing with isopropanol
  4. customThe product is dried

Sources & evidence

ORD record
ord-a3717b33c725487b9848ed040a17d8a4
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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