2-Amino-1-butanol → HCID 178456044, compound

HRID 1453590Notes

Reaction equation

HRID 1453590 reaction equation
[N:1]1([C:10]2[N:18]=[C:17](Cl)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH2:20][CH:21]([CH2:24][CH3:25])[CH2:22][OH:23]>CS(C)=O>[N:1]1([C:10]2[N:18]=[C:17]([NH:20][C@@H:21]([CH2:24][CH3:25])[CH2:22][OH:23])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 221292-Amino-1-butanolHCID 178478376HCID 178478376, compound

Product 1

HCID 178456044HCID 178456044, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

200 mg of product obtained in stage 1 above are mixed with 3 ml of DMSO and 350 μl (5 equivalents) of (+/−)-2-amino-1-butanol, and the mixture is then heated at 120° C. for approximately 2 days. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 95-5-0.3 mixture for eluent. 40 mg of expected product are obtained.

Workup

  1. customto return to ambient temperature
  2. customPurification

Sources & evidence

ORD record
ord-6030d3a0525f4a798c18001d492b4394
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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