HCID 178421931, compound → HCID 178421930, compound

HRID 1453594Notes

Reaction equation

HRID 1453594 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH2:8])[CH2:4][CH2:3]1.[CH3:9][C:10]1[N:11]([C:19]2[NH:27][C:26](Cl)=[N:25][C:24]3[C:20]=2[N:21]=[CH:22][N:23]=3)[C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2>>[CH3:9][C:10]1[N:11]([C:19]2[N:27]=[C:26]([NH:1][C@H:2]3[CH2:7][CH2:6][C@H:5]([NH2:8])[CH2:4][CH2:3]3)[N:25]=[C:24]3[C:20]=2[N:21]=[CH:22][NH:23]3)[C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

3

Reactant 2

HCID 178421931HCID 178421931, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 178421930HCID 178421930, compoundYield 24.1%

Conditions

Temperature
140 °C

Procedure

The same procedure as in stage 2 of Example 1 is carried out, starting from 684 mg of trans-1,4-diaminocyclohexane and 166 mg of the product obtained in stage 2 above, and the mixture is heated at 140° C. for 6 hours. Purification is carried out on silica with MeOH—NH4OH: 98-2 for eluent, and 51 mg of expected product are thus obtained, in the form of beige-colored crystals.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-7f5ec8513257427ea38a86e372add63b
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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