Morpholine → HCID 178478524, compound

HRID 1453598Notes

Reaction equation

HRID 1453598 reaction equation
[N:1]1([C:10]2[N:18]=[C:17]([Cl:19])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>CS(C)=O>[ClH:19].[ClH:19].[N:1]1([C:10]2[N:18]=[C:17]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 178478376HCID 178478376, compound

Product 1

HCID 178478524HCID 178478524, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

230 mg of product obtained in stage 1 above are mixed with 3 ml of DMSO and 370 mg (5 equivalents) of morpholine, and the mixture is then heated at 120° C. for approximately 16 hours. The mixture is allowed to return to ambient temperature. The DMSO is concentrated to dryness. A paste is formed in CH2Cl2 (methylene chloride). Drying is carried out under vacuum. The dry product is taken up in 5 ml of HCl (8M) and 10 ml of ethanol and concentrated to dryness, and 209 mg of expected product are obtained.

Workup

  1. customto return to ambient temperature
  2. concentrationThe DMSO is concentrated to dryness
  3. customA paste is formed in CH2Cl2 (methylene chloride)
  4. customDrying
  5. concentration10 ml of ethanol and concentrated to dryness, and 209 mg of expected product
  6. customare obtained

Sources & evidence

ORD record
ord-98eea0abc2d847a39c89d73057015e42
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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