Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | HCID 178478376 | HCID 178478376 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178478524 | HCID 178478524 | — |
Reaction Steps
230 mg of product obtained in stage 1 above are mixed with 3 ml of DMSO and 370 mg (5 equivalents) of morpholine, and the mixture is then heated at 120° C. for approximately 16 hours. The mixture is allowed to return to ambient temperature. The DMSO is concentrated to dryness. A paste is formed in CH2Cl2 (methylene chloride). Drying is carried out under vacuum. The dry product is taken up in 5 ml of HCl (8M) and 10 ml of ethanol and concentrated to dryness, and 209 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07476670B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-98eea0abc2d847a39c89d73057015e42 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
