HCID 178511674, compound → HCID 178465944, compound

HRID 1453604Notes

Reaction equation

HRID 1453604 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14]1[N:22]=[CH:21][N:20]=[C:19]3[C:15]=1[N:16]=[CH:17][NH:18]3)[CH2:9][CH2:8]2)=[O:4].[NH2:23][C@H:24]1[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]1>O>[NH2:23][C@H:24]1[CH2:29][CH2:28][C@H:27]([NH:30][C:21]2[N:20]=[C:19]3[C:15]([N:16]=[CH:17][NH:18]3)=[C:14]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([C:3](=[O:4])[CH3:2])=[CH:13][CH:12]=4)[CH2:8][CH2:9]3)[N:22]=2)[CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 178511674HCID 178511674, compoundHCID 178520779HCID 178520779, compound

Product 1

HCID 178465944HCID 178465944, compoundYield 115.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
140 °C

Procedure

1.88 g of product obtained in stage 1 above are mixed with 4.8 g of trans-1,4-diaminocyclohexane, and the mixture is then heated at 140° C. for approximately 72 hours. The mixture is allowed to return to ambient temperature for 48 hours. A paste is formed in water, and drying is carried out under vacuum at 50° C. 2.7 g of expected product are obtained, in the form of a beige powder.

Workup

  1. customdrying
  2. customis carried out under vacuum at 50° C

Sources & evidence

ORD record
ord-e416c62ce0dc497eb6466e37daeb3ec7
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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