2,6-Dichloropurine → HCID 178506067, compound

HRID 1453605Notes

Reaction equation

HRID 1453605 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[C:21]2[C:17]([CH2:18][CH2:19][NH:20]2)=[CH:16][CH:15]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:20]2[C:21]3[C:17](=[CH:16][CH:15]=[C:14]([C:13]([F:12])([F:23])[F:24])[CH:22]=3)[CH2:18][CH2:19]2)[N:3]=1

Participants

4

Reactant 2

HCID 53244122,6-DichloropurineHCID 101764376-(Trifluoromethyl)indoline

Product 1

HCID 178506067HCID 178506067, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

756 mg of 2,6-dichloropurine, 8 ml of butanol and 897 mg of 6-(trifluoromethyl)indoline are mixed and brought to a temperature of 90° C. for approximately 23 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum at 50° C. are carried out, and 1.256 g of expected product are obtained, in the form of beige crystals.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum at 50° C.

Sources & evidence

ORD record
ord-7441ed4852aa4a509e750a4802b3e303
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

Loading…