5-Nitroindoline → HCID 178526437, compound

HRID 1453607Notes

Reaction equation

HRID 1453607 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[N+:12]([C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][CH2:19][CH2:18]2)([O-:14])=[O:13]>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:20]2[C:21]3[C:17](=[CH:16][C:15]([N+:12]([O-:14])=[O:13])=[CH:23][CH:22]=3)[CH2:18][CH2:19]2)[N:3]=1

Participants

4

Reactant 2

HCID 362195-NitroindolineHCID 53244122,6-Dichloropurine

Product 1

HCID 178526437HCID 178526437, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

37.8 g of 2,6-dichloropurine, 700 ml of butanol and 32.8 g of 5-nitroindoline are mixed and brought to a temperature of 90° C. for approximately 3 days. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum at 50° C. are carried out and 57.3 g of expected product are obtained, in the form of beige crystals.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum at 50° C.

Sources & evidence

ORD record
ord-d320f36f5fa9491a829b26543dd63f07
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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