Morpholine → Morpholine, 4-(2-chloro-4-nitrophenyl)-

HRID 1453653Notes

Reaction equation

HRID 1453653 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 676882-Chloro-1-fluoro-4-nitrobenzene

Product 1

HCID 108711Morpholine, 4-(2-chloro-4-nitrophenyl)-

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
105 °C

Procedure

1.76 g (10.0 mmol) 3-chloro-4-fluoro-1-nitro-benzene are combined with 2.614 ml (30 mmol) morpholine in 5 ml DMF and heated to 105° C. with stirring for 15 min. The reaction mixture is poured into ice water, the resulting precipitate is suction filtered, washed with water and dried at 50° C. in the drying cupboard.

Workup

  1. filtrationfiltered
  2. washwashed with water
  3. customdried at 50° C. in the drying cupboard

Sources & evidence

ORD record
ord-45b69a4754604d009d53bf22411bdd7c
Source dataset
uspto-grants-2009_01
Patent number
US07476663B2

Reaction notes

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