O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 86602098, compound

HRID 1453656Notes

Reaction equation

HRID 1453656 reaction equation
[C:1]([C@@:8]([NH2:15])([CH2:12][O:13][CH3:14])[C:9]([OH:11])=O)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[N:25]1[CH2:30][CH2:29][O:28][CH2:27][C:26]1=[O:31])[NH:20][CH3:21].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[C:1]([C@@:8]([NH2:15])([CH2:12][O:13][CH3:14])[C:9]([N:20]([CH3:21])[C:19]1[CH:22]=[CH:23][C:24]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][C:26]2=[O:31])=[C:17]([CH3:16])[CH:18]=1)=[O:11])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

5

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 69054022HCID 69054022, compoundHCID 86602099HCID 86602099, compound

Product 1

HCID 86602098HCID 86602098, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1d from (2R)-2-Boc-amino-3-methoxy-propionic acid and 3,N-dimethyl-4-(3-oxo-morpholin-4-yl)-aniline with TBTU and TEA in DMF.

Sources & evidence

ORD record
ord-431cb4f29e8e41aca1dea14cb9b8a5f4
Source dataset
uspto-grants-2009_01
Patent number
US07476663B2

Reaction notes

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