Tetrahydro-4-(2-methyl-4-nitrophenyl)-1,4-oxazepin-5(2H)-one → 3-Methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-aniline

HRID 1453659Notes

Reaction equation

HRID 1453659 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([N+:16]([O-])=O)[CH:5]=[CH:6][C:7]=1[N:8]1[C:14](=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>[Ni].CO>[CH3:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[N:8]1[C:14](=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)[NH2:16]

Participants

4

Reactant 1

HCID 59586730Tetrahydro-4-(2-methyl-4-nitrophenyl)-1,4-oxazepin-5(2H)-one

Product 1

HCID 595867743-Methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-aniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

Prepared analogously to Example 1c from 3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-1-nitro-benzene with Raney nickel under a hydrogen atmosphere in methanol.

Sources & evidence

ORD record
ord-fb5b4ff9ab614ce2b0f5f4d23cb8663f
Source dataset
uspto-grants-2009_01
Patent number
US07476663B2

Reaction notes

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