Sodium Hydroxide → HCID 46890685, compound

HRID 1453681Notes

Reaction equation

HRID 1453681 reaction equation
C([O:5][C:6](=[O:29])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=2)[C:10]([CH:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[S:20](=[O:28])(=[O:27])[NH:19]2)=[CH:9]1)(C)(C)C.[OH-].[Na+]>CCO>[Cl:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([CH2:7][C:6]([OH:29])=[O:5])[CH:9]=[C:10]2[CH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[S:20](=[O:28])(=[O:27])[NH:19]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67316261HCID 67316261, compound

Product 1

HCID 46890685HCID 46890685, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

The product from step c) (100 mg) was dissolved in 3 mL EtOH and treated with 0.5 mL of 1 M NaOH. The reaction was heated to 50° C. for 2 h. Upon cooling, the reaction was washed with DCM, acidified with 1 M HCl, and extracted into DCM. The organic layer was washed twice with water, dried over MgSO4, and concentrated to give the title compound as a solid. MS: ESI (negative): 375, 377 (M−H).

Workup

  1. temperatureUpon cooling
  2. washthe reaction was washed with DCM
  3. extractionextracted into DCM
  4. washThe organic layer was washed twice with water
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-98fe83c2b72e434285e6b927dfad2a9e
Source dataset
uspto-grants-2009_01
Patent number
US07476667B2

Reaction notes

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