Phosphate → 934338-70-2

Participants

Reaction Steps

The salt manufactured at 1 g scale from ethanol was further investigated for its intrinsic dissolution rate and compared to the free base of 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine. The salt had a 1000 times higher intrinsic dissolution rate as compared to the free base. Dissolution rates of the base and salt were measured with a low-volume rotating disc method. Discs were compressed from pure compound and centrically mounted in a disc holder with an exposed area of 0.07 cm2. The disc holder rotated at 500 rpm immersed in 50 mL USP Phosphate buffer pH 6.8 at 37° C. The compound was analyzed UV-Online by a Spectrophotometer with a flow cell and a peristaltic pump with continuous circulation.

Provenance & Evidence