Water → 934282-57-2

HRID 1453811Notes

Reaction equation

HRID 1453811 reaction equation
O.[Cl:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][N:12]=[C:11]([C@H:14]([O:16][C:17]3[N:18]([CH3:28])[C:19]([C:22]4[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=4)=[N:20][N:21]=3)[CH3:15])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[S:29](=[O:33])(=[O:32])([OH:31])[OH:30]>CO>[S:29]([OH:33])([OH:32])(=[O:31])=[O:30].[Cl:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][N:12]=[C:11]([C@H:14]([O:16][C:17]3[N:18]([CH3:28])[C:19]([C:22]4[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=4)=[N:20][N:21]=3)[CH3:15])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 16041426(R)-5-(3-chlorophenyl)-3-(1-((4-Methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)oxy)ethyl)isoxazole

Product 1

HCID 69007598934282-57-2

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An oiled salt was manufactured by evaporating a clear solution obtained by mixing 500 μl water with 33 mg 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine free base, 500 μl methanol and 7 μl 98 wt-% sulphuric acid. The title salt was manufactured by recrystallising the oiled salt in 500 μl ethanol.

Workup

  1. customby evaporating a clear solution
  2. customobtained
  3. customby recrystallising the oiled salt in 500 μl ethanol

Sources & evidence

ORD record
ord-83a06e85bf604f8b98d16bc6fcbaad09
Source dataset
uspto-grants-2009_01
Patent number
US07476684B2

Reaction notes

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