Methylamine → HCID 68893041, compound

HRID 1453834Notes

Reaction equation

HRID 1453834 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([C:28]([O:30]C)=O)=[N:11][N:12]2[CH2:17][CH:16]([CH3:18])[N:15]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[C:14](=[O:27])[C:13]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][NH2:33]>>[CH2:1]([O:8][C:9]1[C:10]([C:28]([NH:33][CH3:32])=[O:30])=[N:11][N:12]2[CH2:17][CH:16]([CH3:18])[N:15]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[C:14](=[O:27])[C:13]=12)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 68891782HCID 68891782, compound

Product 1

HCID 68893041HCID 68893041, compound

Procedure

The title compound was prepared from methyl 3-benzyloxy-5-(4-fluorobenzyl)-6-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate using a procedure similar to that described in Example 5, Step 3, except that methylamine (2M in MeOH) was used in place of 4-fluorobenzylamine, and the reaction was heated to reflux overnight. The solvent was removed in vacuo, and the material was used without purification. ES MS (M+1)=423.

Workup

  1. temperaturethe reaction was heated
  2. temperatureto reflux overnight
  3. customThe solvent was removed in vacuo
  4. customthe material was used without purification

Sources & evidence

ORD record
ord-447598cb27e04c0ea778e977fcb18abc
Source dataset
uspto-grants-2009_01
Patent number
US07476666B2

Reaction notes

Loading…