Hydrogen Bromide → HCID 68953094, compound

HRID 1453850Notes

Reaction equation

HRID 1453850 reaction equation
C([O:8][C:9]1[C:10]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[N:11][N:12]2[CH:17]([C:18]3[S:19][CH:20]=[C:21]([CH3:23])[N:22]=3)[CH2:16][N:15]([CH3:24])[C:14](=[O:25])[C:13]=12)C1C=CC=CC=1.Br>CC(O)=O>[OH:8][C:9]1[C:10]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[N:11][N:12]2[CH:17]([C:18]3[S:19][CH:20]=[C:21]([CH3:23])[N:22]=3)[CH2:16][N:15]([CH3:24])[C:14](=[O:25])[C:13]=12

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 68955890HCID 68955890, compound

Product 1

HCID 68953094HCID 68953094, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 3-benzyloxy-5-methyl-7-(4-methyl-1,3-thiazol-2-yl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (76 mg, 0.178 mmol) was treated with a 5% solution of HBr in AcOH, and the reaction was stirred for 2 hours at room temperature. The solvent was removed in vacuo and the residue azeotroped twice with MeOH to afford the title product as a bright orange solid. ES MS (M+H)=337.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue azeotroped twice with MeOH

Sources & evidence

ORD record
ord-ea829e83384c4a55b67eccca9fdcc9aa
Source dataset
uspto-grants-2009_01
Patent number
US07476666B2

Reaction notes

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