反应详情

To a solution of methyl 3-methoxy-5-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-2-carboxylate (220 mg, 0.7 mmol) in MeOH (5 mL) was added aqueous NaOH (0.91 mL of a 1.0 N solution, 0.91 mmol). The mixture was stirred at ambient temperature for 18 hours. Aqueous HCl (0.16 mL of a 6.0 N solution, 0.96 mmol) was added to the mixture and the solvents were removed under reduced pressure. The residue was triturated in 1:1 MeOH:water and filtered to give the product as a white solid. 1H NMR (400 MHz, d6-DMSO) δ 13.31 (s, 1H), 8.20 (d, J=8.1 Hz, 1H), 7.61 (d, J=7.9 Hz, 1H), 7.55 (t, f=8.0 Hz, 1H), 7.41 (t, J=8.0 Hz, 1H), 7.55 (t, J=8.0 Hz, 1H), 3.99 (s, 3H), 3.60 (s, 3H); ES MS (M+1)=274.

1. customthe solvents were removed under reduced pressure
2. customThe residue was triturated in 1:1 MeOH
3. filtrationwater and filtered