Hydrogen Peroxide → HCID 11666917, compound

HRID 1453929Notes

Reaction equation

HRID 1453929 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[C:6]3[C:12]([CH2:13][S:14][CH2:15][C:16]([NH2:18])=[O:17])=[CH:11][CH:10]=[CH:9][C:7]=3[O:8][C:4]=2[CH:3]=1.[OH:21]O>C(O)(=O)C>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[C:6]3[C:12]([CH2:13][S:14]([CH2:15][C:16]([NH2:18])=[O:17])=[O:21])=[CH:11][CH:10]=[CH:9][C:7]=3[O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 11666663HCID 11666663, compound2×

Product 1

HCID 11666917HCID 11666917, compoundYield 74.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

To a suspension of 2-(7-chlorodibenzofuran-1-ylmethylsulfanyl)acetamide (Example 151 2.56 g, 8.38 mmole) in acetic acid (90 mL), were added 1.4 mL of 35% hydrogen peroxide (14.4 mmole). The mixture was heated at 50° C. for 30 minutes to give a solution, then stirred at RT for 24 hours to give a thick suspension which was filtered, washed by ethanol, ether, dried in vacuum to give 2 g of white solid.

Workup

  1. customto give a solution
  2. customto give a thick suspension which
  3. filtrationwas filtered
  4. washwashed by ethanol, ether
  5. customdried in vacuum

Sources & evidence

ORD record
ord-f9f87c3cab5c4324bbf990030fee1394
Source dataset
uspto-grants-2009_01
Patent number
US07476690B2

Reaction notes

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