反应详情

A solution of 1,1,1-trifluoro-3-iodopropane (263.1 g, 1.17 moles) and triphenylphosphine (924.4 g, 3.52 moles) in toluene (950 mL) was stirred at reflux for 12 hours. The solid product precipitated from the reaction mixture throughout the course of the reaction. The reaction was allowed to cool to ambient temperature and then cooled to about 5° C. in an ice bath. The solid precipitate was isolated by filtration and dried in vacuo at 25° C. to give a white powder (526.5 g, 92%).

1. temperatureat reflux for 12 hours
2. customThe solid product precipitated from the reaction mixture throughout the course of the reaction
3. temperaturecooled to about 5° C. in an ice bath
4. customThe solid precipitate was isolated by filtration
5. customdried in vacuo at 25° C.