反应详情

A suspension of benzyl 4-amino-2-(4-bromophenyl)-4-oxobutanoate (1.53 g, 4.22 mmol) and platinum(IV) oxide (30 mg) in ethanol (100 mL) was stirred under an hydrogen atmosphere for 2 h. After replacement of hydrogen with nitrogen the crude reaction mixture was filtered through a thin pad of celite and the filtrate evaporated to dryness to give the title compound as a cream coloured solid (1.14 g, 100%). LC/MS: 2.36 min; z/e 272 and 274, calcd (M+1) 272 and 274. 1H NMR (400 MHz: DMSO-d6): 7.50 (2H), 7.30 (1H), 7.20 (2H), 6.80 (1H), 3.90 (1H), 2.80 (1H), 2.40 (1H).

1. customAfter replacement of hydrogen with nitrogen the crude reaction mixture
2. filtrationwas filtered through a thin pad of celite
3. customthe filtrate evaporated to dryness