HRID1454194
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 80 °C
PROCEDURE
实验过程
A mixture of tert-butyl 3-methoxybenzyl((2R,3S)-3-(3-acetyl-5-(benzamido)benzamido)-4-(3,5-difluorophenyl)-2-hydroxybutyl)carbamate (10 mg, 0.0147 mmol) and hydroxyamine hydrochloride (2.0 mg, 0.0294 mmol) in ethanol (0.1 mL) was heated at 80° C. for 2 h. The reaction mixture was purified by reverse phase prep HPLC to give the title compound: HPLC retention time: 2.16 min (method A). MS (ESI) (M+H)+ 697.90
WORKUP
后处理
- customThe reaction mixture was purified by reverse phase prep HPLC