Acetate → 7-Fluoro-1-methyl-5-nitro-1,3-dihydro-indol-2-one

HRID 145423Notes

Reaction equation

HRID 145423 reaction equation
[C:17]([P:18]([C:19]([CH3:20])([CH3:21])[CH3:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][c:28]1-[c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)([CH3:35])([CH3:36])[CH3:37].[C:45]([O-:46])(=[O:47])[CH3:48].[C:50]([O-:51])(=[O:52])[CH3:53].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[CH3:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1.[Cl:1][CH2:2][C:3](=[O:4])[N:5]([CH3:6])[c:7]1[c:8]([F:16])[cH:9][c:10]([N+:13](=[O:14])[O-:15])[cH:11][cH:12]1.[Pd+2:49]>>[CH2:2]1[C:3](=[O:4])[N:5]([CH3:6])[c:7]2[c:8]([F:16])[cH:9][c:10]([N+:13](=[O:14])[O-:15])[cH:11][c:12]21

Participants

7

Reactant 6

HCID 175Acetate2×HCID 1140TolueneHCID 8471TriethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27342152-(Di-tert-butylphosphino)biphenylHCID 119518482-chloro-N-(2-fluoro-4-nitrophenyl)-N-methylacetamide

Product 1

HCID 119516757-Fluoro-1-methyl-5-nitro-1,3-dihydro-indol-2-one

Sources & evidence

ORD record
ord-ee9fdff9aa6a45f2b73abb4326078b95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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