HRID1454323

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3821

Ketamine

C13H16ClNO

HCID4171

Metoprolol

C15H25NO3

HCID4946

Propranolol

C16H21NO2

HCID5707

Xylazine

C12H16N2S

$结构：CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2.O=C(O)/C=C\C(=O)O$

HCID6420038

Acetopromazine maleate

C23H26N2O5S

结构：O[C@@H]1[C@H](O)[C@@H](CSc2ccccc2F)O[C@H]1n1cnc2c(N[C@@H]3CCC[C@H]3O)ncnc21

HCID11561692

GS-9667

C21H24FN5O4S

PRODUCTS

生成物

HCID59768

Esmolol

C16H25NO4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Rats (Sprague Dawley) weighing 300-400 gms were purchased from Simonsen laboratories. CVT-3619 was dissolved in DMSO and further diluted in saline. CVT-510 was dissolved in saline. Ketamine was purchased from Fort Dodge Animal Health, Xylazine from Bayer and Acepromazine Maleate from Fermenta Animal Health Co. Metoprolol and propranolol were purchased from SIGMA. Esmolol was obtained from a local pharmacy.

WORKUP

后处理

additionfurther diluted in saline
dissolutionCVT-510 was dissolved in saline

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4b75149209604688b19e1400bc412ecb
来源数据集: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07479485B2
来源说明: uspto-grants-2009_01

反应 SMILES

[CH:1]1C=CC(SC[C@H]2O[C@@H](N3C4=NC=NC(N[C@H]5[C@H](O)CCC5)=C4N=C3)[C@H](O)[C@@H]2O)=C(F)C=1.CNC1(C2C=CC=CC=2Cl)C(=O)CCCC1.CC1C=CC=C(C)C=1NC1SCCCN=1.CC(C1C=CC2SC3C=CC=CC=3N(CCCN(C)C)C=2C=1)=O.[CH:87](/[C:92](O)=O)=[CH:88]/[C:89]([OH:91])=[O:90].[CH3:95][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105]C(CCOC)=[CH:107][CH:108]=1)[CH3:97].CC(NCC(O)COC1C=CC=C2C=CC=CC=12)C>CS(C)=O>[CH3:97][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105][C:92]([CH2:87][CH2:88][C:89]([O:91][CH3:1])=[O:90])=[CH:107][CH:108]=1)[CH3:95]