反应详情

温度

9 °C

50 g of donepezil was dissolved by stirring in 240 g of ethanol under heating, followed by adding 15.1 g of concentrated hydrochloric acid thereto at the internal temperature of 30° C. Then, it was cooled and continued stirring while keeping the internal temperature at about 25° C. Crystals started precipitating about 1 hour after the concentrated hydrochloric acid was poured into the mixture. After the precipitation started, the mixture was stirred at the internal temperature of 25° C. for 17 hours and then cooled to the internal temperature of 9° C. The crystals were collected by filtration and dried about 3 hours after the cooling was started, to give 52.25 g of polymorphic crystal (III) of donepezil hydrochloride (yield: 95.3%).

1. temperatureunder heating
2. customat the internal temperature of 30° C
3. temperatureThen, it was cooled
4. customat about 25° C
5. customCrystals started precipitating about 1 hour after the concentrated hydrochloric acid
6. additionwas poured into the mixture
7. customAfter the precipitation
8. stirringthe mixture was stirred at the internal temperature of 25° C. for 17 hours
9. filtrationThe crystals were collected by filtration
10. customdried about 3 hours after the cooling