Hydrochloric Acid → 3-(4-Benzyloxy-3,5-dimethyl-phenyl)-2-oxo-propionic acid

HRID 1454380Notes

Reaction equation

HRID 1454380 reaction equation
C(N[C:5](=[CH:10][C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:13]([CH3:26])[CH:12]=1)[C:6]([O:8]C)=[O:7])(=O)C.Cl.[O:28]1CCOCC1>>[CH2:19]([O:18][C:14]1[C:15]([CH3:17])=[CH:16][C:11]([CH2:10][C:5](=[O:28])[C:6]([OH:8])=[O:7])=[CH:12][C:13]=1[CH3:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67273532Methyl 2-acetylamino-3-(4-benzyloxy-3,5-dimethyl-phenyl)-acrylate

Product 1

HCID 672738733-(4-Benzyloxy-3,5-dimethyl-phenyl)-2-oxo-propionic acid

Procedure

31.1 g (88.1 mmol) methyl 2-acetylamino-3-(4-benzyloxy-3,5-dimethyl-phenyl)-acrylate in 150 mL 1,4-dioxane were combined with 125 mL 4 M HCl, stirred for 7 h at reflux temperature and stirred overnight at RT. The precipitate was suction filtered, washed with water and dried at 45° C. in the vacuum drying cupboard.

Workup

  1. temperatureat reflux temperature
  2. stirringstirred overnight at RT
  3. filtrationfiltered
  4. washwashed with water
  5. customdried at 45° C. in the vacuum
  6. customdrying cupboard

Sources & evidence

ORD record
ord-eb1348f1eb864b07be7dfe86a14f09e7
Source dataset
uspto-grants-2009_01
Patent number
US07479488B2

Reaction notes

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