Ethyl-5-bromo-2-carboxypyridine → 1-(5-Bromopyridin-2-yl)cyclopentan-1-ol

HRID 1454406Notes

Reaction equation

HRID 1454406 reaction equation
C([C:3]1[C:4]([C:10]([OH:12])=O)=[N:5][CH:6]=[C:7]([Br:9])[CH:8]=1)C>C(OCC)C>[Br:9][C:7]1[CH:8]=[CH:3][C:4]([C:10]2([OH:12])[CH2:7][CH2:8][CH2:3][CH2:4]2)=[N:5][CH:6]=1

Participants

3

Reactant 1

HCID 67144082Ethyl-5-bromo-2-carboxypyridine

Product 1

HCID 690609981-(5-Bromopyridin-2-yl)cyclopentan-1-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepared using ethyl-5-bromo-2-carboxypyridine, 1,4-bis (bromomagnesium) butane and diethyl ether as solvent, but otherwise followed the general procedure for Preparation 36. 13C NMR (100 MHz, CDCl3) d 164.1, 148.9, 139.5, 120.9, 118.8, 83.2, 42.7, 24.9; MS (AP/Cl) 242.1, 244.1 (M+H)+.

Workup

  1. customfor Preparation 36

Sources & evidence

ORD record
ord-11c64e62e8c84a3e82c21855e36b08a1
Source dataset
uspto-grants-2009_01
Patent number
US07479559B2

Reaction notes

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