反应详情

To a solution of compound 7-(1,4′-bipiperidin-1′-yl)-5-chloro-1-(2,6-difluorophenyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (18 mg, 0.04 mmol) in dioxane (1.5 mL)/water (0.5 mL) were added potassium carbonate (34 mg, 0.25 mmol), tetrakis(triphenylphosphine)palladium(0) (2.3 mg, 0.002 mmol) and N-(4-fluorophenyl)-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (22 mg, 0.062 mmol).The reaction mixture was bubbled with N2 for 5 mins, then microwaved at about 150° C. for about 30 mins. The reaction mixture was concentrated. CombiFlash chromatography (mobile phase DCM/DCM[90]+MeOH [7]+NH4OH[3]) provided the title compound as a white solid (13 mg, 51%). LC-MS m/z 656 (M+H)+; 1H-NMR (CD3OD) δ 1.37 (m, 2 H), 1.48 (m, 2 H), 1.60 (m, 4 H), 1.80 (m, 2 H), 2.33 (s, 3 H), 2.56 (m, 5 H), 2.72 (t, 2 H), 4.17 (m, 2 H), 4.46 (m, 2 H),7.12 (m, 4 H), 7.52 (m, 2 H), 7.72 (m, 2 H), 7.82 (s, 1 H), 7.98 (d, 1 H).

1. customwas bubbled with N2 for 5 mins
2. custommicrowaved at about 150° C. for about 30 mins
3. concentrationThe reaction mixture was concentrated