p-Toluenesulfonic acid → HCID 86613469, compound

HRID 1454672Notes

Reaction equation

HRID 1454672 reaction equation
[CH2:1]([C:5]1[N:6]([C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][N:24]([S:28]([C:31]3[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=3)(=[O:30])=[O:29])[C:25](=[O:27])[O-:26])=[CH:18][CH:17]=2)[C:7]2[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([CH3:14])[C:8]=2[N:15]=1)[CH2:2][CH2:3][CH3:4].[CH3:38][C:39]1[CH:40]=[CH:41][C:42]([S:45]([OH:48])(=[O:47])=[O:46])=[CH:43][CH:44]=1>CO>[CH2:1]([C:5]1[N:6]([C:16]2[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][N:24]([S:28]([C:31]3[CH:32]=[CH:33][C:34]([CH3:37])=[CH:35][CH:36]=3)(=[O:29])=[O:30])[C:25](=[O:26])[O-:27])=[CH:20][CH:21]=2)[C:7]2[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([CH3:14])[C:8]=2[N:15]=1)[CH2:2][CH2:3][CH3:4].[CH3:38][C:39]1[CH:44]=[CH:43][C:42]([S:45]([OH:48])(=[O:47])=[O:46])=[CH:41][CH:40]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 21876535HCID 21876535, compound

Product 1

HCID 86613469HCID 86613469, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[4-(2-butyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl(4-methylphenyl)sulfonylcarbamate (Example 230) in methanol was added TsOH (1.0 eq.). The resulting mixture was stirred at room temperature for 5 min and concentrated. The residual solids were collected and dried under reduced pressure at 50° C. to afford the title compound as white solids:

Workup

  1. concentrationconcentrated
  2. customThe residual solids were collected
  3. customdried under reduced pressure at 50° C.

Sources & evidence

ORD record
ord-637288dec9d3473e9eb7c38b587be136
Source dataset
uspto-grants-2009_01
Patent number
US07479564B2

Reaction notes

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