1-(4-Morpholinophenyl)-1-phenylprop-2-yn-1-ol → 3-phenyl-3-(4-morpholinophenyl)-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran

HRID 1454744Notes

Reaction equation

HRID 1454744 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([OH:16])[C:14]#[CH:15])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[CH3:23][C:24]1([CH3:42])[C:36]2[CH:35]=[C:34](O)[C:33]3[CH:38]=[CH:39][CH:40]=[CH:41][C:32]=3[C:31]=2[C:30]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]1=2>>[C:17]1([C:13]2([C:10]3[CH:9]=[CH:8][C:7]([N:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)=[CH:12][CH:11]=3)[O:16][C:34]3[C:33]4[CH:38]=[CH:39][CH:40]=[CH:41][C:32]=4[C:31]4[C:30]5[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=5)[C:24]([CH3:42])([CH3:23])[C:36]=4[C:35]=3[CH:15]=[CH:14]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2867411-(4-Morpholinophenyl)-1-phenylprop-2-yn-1-olHCID 666108027,7-dimethyl-7H-benzo[C]fluoren-5-ol

Product 1

HCID 685322733-phenyl-3-(4-morpholinophenyl)-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran

Procedure

The process for Step 3 of Example 1 was followed except that 1-(4-morpholinophenyl)-1-phenyl-2-propyn-1-ol (from Step 2) was used instead of 1-ferrocenyl-1-phenyl-2-propyn-1-ol to react with 7,7-dimethyl-7H-benzo[C]fluoren-5-ol to provide 3-phenyl-3-(4-morpholinophenyl)-13,13-dimethyl-3H,13H-indeno[2′,3′:3,4]naphtho[1,2-b]pyran. Mass spectrometry analysis supported a molecular weight consistent with 3-phenyl-3-(4-morpholinophenyl)-13,13-dimethyl-3H,13H-indeno[2′,3′:3,4]naphtho[1,2-b]pyran.

Sources & evidence

ORD record
ord-560b2e9c03a4457196291a7b6ad374a3
Source dataset
uspto-grants-2009_01
Patent number
US07481955B2

Reaction notes

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