Hydrochloric Acid → HCID 86609585, compound

HRID 1454775Notes

Reaction equation

HRID 1454775 reaction equation
C(OCC)C.[CH3:6][S:7][C:8]([N:10]1[CH2:15][C:14]([CH:19]([CH3:21])[CH3:20])([CH:16]([CH3:18])[CH3:17])[CH2:13][S:12][C:11]1=[N:22][C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([N:33]([CH3:35])[CH3:34])=[CH:25][CH:24]=1)=[S:9].[ClH:36]>O1CCOCC1>[ClH:36].[CH3:6][S:7][C:8]([N:10]1[CH2:15][C:14]([CH:19]([CH3:21])[CH3:20])([CH:16]([CH3:17])[CH3:18])[CH2:13][S:12][C:11]1=[N:22][C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([N:33]([CH3:35])[CH3:34])=[CH:25][CH:24]=1)=[S:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57531152HCID 57531152, compound

Product 1

HCID 86609585HCID 86609585, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a diethyl ether (5 mL) solution of 3-[(methylthio)thiocarbonyl]-2-(4-dimethylamino-1-naphthylimino)-5,5-diisopropyl-1,3-thiazine (I-43: 0.15 g), was added 4N dioxane solution of hydrochloric acid (0.23 mL), and the reaction mixtuer was stirred at room temperature for 0.5 h. The resulting crystals were filterd to obtain 3-[(methylthio)thiocarbonyl]-2-(4-dimethylamino-1-naphthylimino)-5,5-diisopropyl-1,3-thiazine hydrochloric acid salt (I-152: 0.14 g, 94%) as yellow crystals.

Sources & evidence

ORD record
ord-7d214579924b446c816a7eefe8501a03
Source dataset
uspto-grants-2009_01
Patent number
US07482339B2

Reaction notes

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