Carbon Dioxide → HCID 68842366, compound

HRID 1454816Notes

Reaction equation

HRID 1454816 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:5]=[CH:4][CH:3]=1.C([N-]C(C)C)(C)C.[Li+].[C:33](=[O:35])=[O:34]>C1COCC1.CCCCCCC.C(C1C=CC=CC=1)C>[F:24][C:21]1[CH:20]=[CH:19][C:18]([C:15]2[CH:16]=[CH:17][C:12]([S:9]([NH:8][C:6]3[N:7]=[C:2]([CH2:1][C:33]([OH:35])=[O:34])[CH:3]=[CH:4][CH:5]=3)(=[O:11])=[O:10])=[CH:13][CH:14]=2)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 2724682Lithium diisopropylamideHCID 44143308HCID 44143308, compound

Product 1

HCID 68842366HCID 68842366, compound

Reagents, catalysts & solvents 1

HCID 22742125Tetrahydrofuran heptane ethylbenzolSolvent

Procedure

This material was obtained in analogy to example 71 step A] from 4′-fluoro-biphenyl-4-sulfonic acid (6-methyl-pyridin-2-yl)-amide (0.5 g, product of example 17), 1.46 mL of a 2 M lithium diisopropylamide solution in THF/heptane/ethylbenzene, and dry ice to give [6-(4′-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid as a gum (0.69 g) that was used without further purification in the next step.

Sources & evidence

ORD record
ord-ebd55cb091494ba69c436805e537d7a3
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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