Sodium Hydroxide → 6-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

HRID 1454822Notes

Reaction equation

HRID 1454822 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH:15]C(=O)C(C)(C)C)[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68842438N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

Product 1

HCID 688451406-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.825 g) and 3M aqueous NaOH (4.35 mL) as a yellow oil (0.596 g). MS (ESI): 233.1 (MH+).

Sources & evidence

ORD record
ord-c074a530cc194ec2a2886d5018e99a38
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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