Bromomethylcyclopropane → N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide

HRID 1454837Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])=[N:7][CH:8]=1.Br[CH2:17][CH:18]1[CH2:20][CH2:19]1>>[CH:18]1([CH2:17][O:1][CH2:2][C:3]2[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:12])([CH3:14])[CH3:13])=[N:7][CH:8]=2)[CH2:20][CH2:19]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 24229196N-(5-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 68842953N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Procedure

This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (1.04 g) and bromomethyl cyclopropane (0.813 g) as a light yellow oil (0.87 g). MS (ESI): 263.1. (MH+).

Sources & evidence

ORD record: ord-98f71323a1f043d69814913ac1aa20fe
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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