Sodium Hydroxide → 5-Cyclopropylmethoxymethyl-pyridin-2-ylamine

HRID 1454838Notes

Reaction equation

[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH:13]C(=O)C(C)(C)C)=[N:11][CH:12]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68842953N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 621942995-Cyclopropylmethoxymethyl-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.87 g) and 3M aqueous NaOH (5.54 mL) as a yellow solid (0.527 g). MS (ESI): 179.1 (MH+).

Sources & evidence

ORD record: ord-fc2b903cbe9447549cee38f323843824
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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