Sodium borohydride → N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

HRID 1454842Notes

Reaction equation

[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][C:8]=1[CH3:9])=[O:2].[BH4-].[Na+]>>[OH:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:14])([CH3:13])[CH3:15])=[N:7][C:8]=1[CH3:9]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 86233848N-(5-Formyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 68844472N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Procedure

This material was prepared in analogy to example 107 step B] from N-(5-formyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (5.9 g) and sodium borohydride (1.037 g) as a light yellow solid (1.41 g). MS (ESI): 223.2 (MH+).

Sources & evidence

ORD record: ord-52bf7552bd1a410190dda7ea9a0d3bfd
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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